大师讲堂预告 | 黄乃正教授为你分享有机合成的科学

香港中文大学（深圳）荣幸地邀请到了香港中文大学新亚书院院长黄乃正教授做客“大师讲堂”，他将与我们分享有机合成的科学。

本期“大师讲堂”将于3月30日（星期一）下午15:00在Zoom直播，欢迎我校师生的参与。

讲座安排

Schedule

主题：有机合成的科学

主讲嘉宾：黄乃正教授

日期：3月30日（星期一）下午15:00开始

直播平台：Zoom

https://cuhksz.网址未加载/j/544357564

会议 ID：544 357 564

语言：英文

Topic:The Science ofOrganic Synthesis

Speaker:Professor Henry N.C. Wong

Date: 15:00pm, Monday, March 30

Live Streaming Platform：Zoom

https://cuhksz.网址未加载/j/544357564

Event ID：544 357 564

Language:English

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嘉宾简介

Speaker Profile

黄乃正教授

黄乃正教授现任香港中学新亚书院院长、荣休化学讲座教授及研究教授。他曾任该校副校长（20092013年）及理学院院长（20122018年）。

黄教授主要研究天然及非天然化合物的有机合成。黄教授发表了超过260篇研究论，邀请评论和书籍章节，并在60多个化学研讨会作会或邀请报告。他是许多国际有机化学期刊编辑委员或顾问委员。他为中国的科研发展做出积极贡献，现为中国科学院上海有机化学研究所沪港化学合成联合实验室管理委员会主席，并出任多所内地学的客座及名誉教授。

黄教授曾获多项殊荣，包括伦敦学科学博学位，中国国家自然科学等奖（1997）、 香港裘槎优秀科研者奖（1999）。他分别于1999年及2004年获选中国科学院院及发展中世界科学院院（前称第三世界科学院）。黄教授于2015年获选香港科学院创院院。

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Professor Henry N.C. Wong is currently Head of New Asia College, Emeritus Professor of Chemistry, and Research Professor at The Chinese University of Hong Kong.He was ProVice-Chancellor/Vice-President for Research of the University from 2009 to 2013, and Dean of Science from 2012 to 2018.

The research areas of Professor Wong are in organic syntheses of natural and non-natural molecules.Professor Wong has published more than 260 research papers, invited reviews and book chapters. He also presented more than 60 plenary and invited lectures in international symposia and conferences, and serves as editorial and advisory board members of many international journals. In addition, Professor Wong proactively contributes to the development of scientific research on the mainland. He is the Chairman of the Management Committee, Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, The Chinese Academy of Sciences. He is also Guest Professor and Honorary Professor of many mainland universities.

To recognise his contributions, Professor Wong has received many honours, including D.Sc. from University of London (1994), 2nd Class National Natural Science Prize of China (1997) and Croucher Senior Research Fellowship (1999). He is also Member of The Chinese Academy of Sciences (1999) and Fellow of The World Academy of Sciences for the advancement of science in developing countries (2004). Professor Wong was elected Founding Member of The Hong Kong Academy of Sciences in 2015.

摘要

Abstract

本次讲座将围绕有机合成作为一门科学的各方面展开讨论。首先，讲者将解读有机化学合成的限制条件和范畴。讲者还将分享其在香港和上海进行的研究成果，包括含羟基的四苯并环辛四烯 （Hydroxytetraphenylenes）的合成和研究。他将介绍部分正在进行的项目所取得的进展，包括富勒烯-C76的手性识别，有机锂化合物的铁催化交叉偶联反应，以及尝试从大豆叶片中分离引起植物超敏反应（HR）的特定受体蛋白质的研究（超敏反应会导致局部细胞死亡以及抗微生物植物抗毒素的积累）。

天然产物的复杂分子全合成是一种高难度的化学合成。讲者将通过Cryptotrione全合成的案例详细介绍该类型合成的难点（Cryptotrione是一种从日本雪松的树皮中分离出来的天然产物，具有独特的五元螺环与环丙烷融合等特点）。最后，讲者将分享有机合成化学所面临的挑战，以及对有机合成的未来作一总结。

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This talk will centre around various aspects of organic synthesis as a science. First, constraints and scope of organic synthesis will be given. Then, discussion will be mainly on the speaker’s own research works carried out in Hong Kong and Shanghai, which include the synthesis and studies of hydroxytetraphenylenes, iron-catalyzed cross-coupling reactions employing organolithium compounds, and natural products synthesis.

The total synthesis of cryptotrione, isolated from the bark of C. japonica (Japanese cedar) and featuring a unique 5-membered spiro-ring fused with a cyclopropane, will be presented in detail to showcase the difficulties involved in total synthesis of structurally complex naturally occurring molecules. Furthermore, progresses on some on-going projects, such as chiral recognition of fullerene C76, and isolation of the specific receptor protein from soybean leaves responsible for the hypersensitive defense response (HR) to cause localized cell death and accumulation of antimicrobial phytoalexins, will be presented. In the conclusion, some grand challenges for synthetic organic chemists, as well as the future of organic synthesis will be delineated.

CUHK-Shenzhen Master Forum

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